I'll be attending PyCon this year. It's been a few years since I've attended and wow has it ever grown: 11 keynotes, 120 talks, 5 hours of lightning talks, the Python Language Summit, preceded by tutorial days and followed by days of sprints.
I'm looking forward to diving back into pure Python for a little while -- something I've had difficulty finding the time for with my work on Komodo. I'm especially looking forward to the "Package distribution & installation" session at the Python Language Summit, not the least of which is because ActiveState is starting to devote more resources to this area. My newest co-worker Sridhar Ratnakumar is currently looking at how ActiveState can help here.